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Smoking – what all healthcare professionals need to know by Dr. Graham F. Cope
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IsoScreen is a urine test to monitor treatment adherence of patients with tuberculosis.
Isoniazid therapy is the mainline drug treatment for TB. The course of treatment is long and arduous, every day for 6-
TB treatment adherence Isoniazid metabolites in urine
Many patients do not complete their course of treatment. Unfortunately, this non-
We have incorporated a test for isoniazid into SafeTube to produce a 5-
A recent audit of treatment compliance by patients attending a TB outpatient clinic showed that over 5% of patients were not taking their treatment correctly. The test therefore indicated which patients required extra monitoring or an alternative treatment regimen (Ann Clin Biochem 2004).
Independent studies have used IsoScreen to assess electronic monitoring of treatment adherence (den Boogaard), to monitor treatment adherence following home-
A study was carried out to determine the colour change of the IsoScreen test with time following the last dose of isoniazid. Of 99 results from TB patients who has just finished their isoniazid treatment within 12 hours, all urine samples were positive -
Over time, the proportion of green and yellow results increased. There was a highly significant probability of a purple result at 12 hours, blue at 24 hours, green at 36 hours and yellow at 72 hours (OR 0.84, p=0.0001). All healthy controls gave a negative result. There was no association with acetylator status (TB Conference, London 2013)
IsoScreen kit contains 10 tests in foil pouches
and an instruction leaflet.
Fill the syringe with urine and place onto the plastic tube. Holding the tube in both hands on a firm surface, place both thumbs on the sides of the cap and snap the cap on quickly
Push down on the syringe to expel its contents into the tube and then mix by flicking the tube vigorously for 30 seconds.
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1. IsoScreen kit ordering code: GFC 007